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There are 4 eight-letter words beginning with EPE

EPEEISTSepeeists n. Plural of epeeist.
épéeists n. Plural of épéeist.
EPEEIST n. one who fences with an epee.
EPEIRIDSepeirids n. Plural of epeirid.
EPEIRID n. a member of the family Epeiridae, that includes garden spiders, also EPEIRA.
EPENDYMAependyma n. (Anatomy) The thin membrane of glial cells lining the ventricles of the brain and the central canal…
EPENDYMA n. a membrane lining certain body cavities.
EPERGNESepergnes n. Plural of epergne.
épergnes n. Plural of épergne.
EPERGNE n. (French) a branched ornamental centrepiece.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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