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There are 2 six-letter words beginning with EPU

EPUISEEPUISE adj. (French) exhausted (of a male).
EPULISepulis n. (Medicine) A hard tumour or tumorous growth developed from the gums.
EPULIS n. (Greek) a tumor of the gums.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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