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There are 6 four-letter words beginning with ES

ESESeses n. Plural of ese.
ES n. the letter S, also ESS.
ESKYesky n. (Australia) An insulated picnic cooler, using ice or refrigerated blocks to keep food and drinks cool.
ESKY n. a container for keeping drinks cool.
ESNEesne n. (Anglo-Saxon, historical) A hireling of servile status; slave.
ESNE n. (historical) a domestic slave in Old English times.
ESPYespy v. (Transitive).
espy v. (Intransitive, archaic) To observe as a spy, to spy; also, to examine or observe carefully; or to look out or watch.
espy n. (Countable).
ESSEesse n. Essence, essential nature.
ESSE n. (Latin) actual existence, essence.
ESTSESTs n. Plural of EST.
EST n. a programme designed to develop human potential.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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