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There are 3 five-letter words beginning with CIS

CISCOcisco n. Any North American freshwater fish of certain species of the genus Coregonus that live in cold-water lakes.
Cisco prop.n. Cisco Systems, Inc., a manufacturer of routers, switches, and other networking and communications equipment.
CISCO n. a North American lake fish.
CISSYcissy n. Alternative spelling of sissy.
cissy n. (Slang, rare, often humorous, sometimes derogatory) A cisgender or cissexual person.
Cissy prop.n. A female given name, diminutive of Cicely.
CISTScists n. Plural of cist.
CIST n. a tomb consisting of a stone chest covered with stone slabs.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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