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There are 6 eight-letter words beginning with ASPIR

ASPIRANTaspirant n. Someone who aspires to high office, etc.
aspirant adj. Seeking advancement.
aspirant adj. Striving for recognition.
ASPIRATAASPIRATA n. (Latin) a breathed sound like "ph" or "th".
ASPIRATEaspirate n. (Linguistics) The puff of air accompanying the release of a plosive or fricative consonant.
aspirate n. (Linguistics) A sound produced by such a puff of air.
aspirate n. A mark of aspiration (#) used in Greek; the asper, or rough breathing.
ASPIRERSaspirers n. Plural of aspirer.
ASPIRER n. one who aspires.
ASPIRINGaspiring adj. Hoping to become.
aspiring v. Present participle of aspire.
aspiring n. (Archaic) Aspiration.
ASPIRINSaspirins n. Plural of aspirin.
ASPIRIN n. a pain relieving drug.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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