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There are 12 twelve-letter words containing S, 3T and 2U

AUTODESTRUCTautodestruct v. (Intransitive, chiefly science fiction) To destroy itself by design (as of a mechanical system).
autodestruct n. (Chiefly science fiction) A feature of a system whereby it destroys itself.
AUTODESTRUCT v. to self-destruct.
OUTTHRUSTINGoutthrusting v. Present participle of outthrust.
OUTTHRUST v. to extend outwards.
SCUTTLEBUTTSscuttlebutts n. Plural of scuttlebutt.
scuttle-butts n. Plural of scuttle-butt.
SCUTTLEBUTT n. a drinking fountain on a ship; gossip.
SKUTTERUDITEskutterudite n. (Mineralogy) A class of mixed cobalt and nickel arsenide and sulfide minerals.
SKUTTERUDITE n. a cubic mineral, cobalt arsenide.
SUBSTITUENTSsubstituents n. Plural of substituent.
SUBSTITUENT n. a thing, esp. an atom, substituted for another.
SUBSTITUTINGsubstituting v. Present participle of substitute.
SUBSTITUTE v. to put or use in the place of another.
SUBSTITUTIONsubstitution n. The act of substituting or the state of being substituted.
substitution n. A substitute or replacement.
substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another.
SUBSTITUTIVEsubstitutive adj. Characteristic of, or serving as a substitute.
SUBSTITUTIVE adj. serving or suitable as a substitute.
TRUSTBUSTERStrustbusters n. Plural of trustbuster.
TRUSTBUSTER n. a person who works for or achieves the breakup of business trusts, e.g. by legislation.
TRUSTBUSTINGtrustbusting n. (US) The breaking up of trusts or monopolies.
TRUSTBUSTING n. the dissolution of corporate trusts.
UNSTATUTABLEunstatutable adj. Not statutable.
UNSTATUTABLE adj. contrary to statute.
UNSTATUTABLYunstatutably adv. In an unstatutable manner.
UNSTATUTABLE adv. contrary to statute.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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