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There are 12 words containing 2P, 3S and 2U

IMMUNOSUPPRESSimmunosuppress v. (Transitive) To cause immunosuppression in.
IMMUNOSUPPRESS v. to inhibit the body's immune response.
PERSPICUOUSNESSperspicuousness n. The state or characteristic of being perspicuous; perspicuity.
PERSPICUOUSNESS n. the state of being perspicuous.
POPULOUSNESSpopulousness n. The quality of being populous.
POPULOUSNESS n. the state of being populous.
POPULOUSNESSESPOPULOUSNESS n. the state of being populous.
PURPOSEFULNESSpurposefulness n. The state of being purposeful.
PURPOSEFUL n. showing purpose.
SUPERPLUSESsuperpluses n. Plural of superplus.
SUPERPLUS n. (obsolete) a surplus.
SUPPOSITIOUSsuppositious adj. Spurious; substituted for the genuine, counterfeit; fake; supposititious.
suppositious adj. Imaginary; fictitious, pretended to exist.
suppositious adj. Hypothetical, based on supposition; suppositional.
SUPPOSITIOUSLYsuppositiously adv. In a suppositious manner.
SUPPOSITIOUS adv. fraudulently substituted, also SUPPOSITITIOUS.
SUPPOSITITIOUSsupposititious adj. (Obsolete) Spurious; substituted for the genuine, counterfeit; fake.
supposititious adj. (Obsolete) Imaginary; fictitious, pretended to exist.
supposititious adj. Supposed or hypothetical.
UNSUPPLENESSunsuppleness n. The quality of not being supple.
UNSUPPLENESS n. the state of being unsupple.
UNSUPPLENESSESUNSUPPLENESS n. the state of being unsupple.
UNSUPPRESSEDunsuppressed adj. Not suppressed.
UNSUPPRESSED adj. not suppressed.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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