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There are 4 twelve-letter words containing P, 2R, 2T and 2U

PRESTRUCTUREprestructure v. To structure in advance.
PRESTRUCTURE v. to structure in advance.
RUPTUREWORTSruptureworts n. Plural of rupturewort.
RUPTUREWORT n. a caryophyllaceous plant once thought to cure hernia.
SUPERSTRATUMsuperstratum n. (Geology) A stratum that is on top of another.
superstratum n. (Linguistics) A language imposed upon a population that previously spoke another language.
SUPERSTRATUM n. an overlying layer.
SUPERSTRUCTSsuperstructs v. Third-person singular simple present indicative form of superstruct.
SUPERSTRUCT v. to build on something else as a foundation.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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