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There are 13 twelve-letter words containing 2P, R, S and 2U

MULTIPURPOSEmultipurpose adj. Designed or intended to fit more than one type of function or application; having multiple uses.
multi-purpose adj. Alternative form of multipurpose.
MULTIPURPOSE adj. having many purposes.
PAPULIFEROUSpapuliferous adj. Pimply; covered with papulae.
PAPULIFEROUS adj. pimply.
PERSULPHURICPERSULPHURIC adj. denoting a type of acid, also PERSULFURIC.
PRESUMPTUOUSpresumptuous adj. Going beyond what is right, proper, or appropriate because of an excess of self-confidence or arrogance.
PRESUMPTUOUS adj. overstepping due bounds (as of propriety or courtesy).
PURPOSEFULLYpurposefully adv. In a purposeful manner.
purposefully adv. (Proscribed) On purpose, purposely, deliberately.
PURPOSEFUL adv. showing purpose.
PURPRESTURESpurprestures n. Plural of purpresture.
PURPRESTURE n. encroachment on public property.
SUPERPREMIUMsuperpremium adj. Of greatly superior quality, beyond premium.
superpremium n. A product or brand of greatly superior quality, beyond premium.
SUPERPREMIUM n. a very large premium.
SUPPURATIONSsuppurations n. Plural of suppuration.
SUPPURATION n. the discharge of pus.
SUPPURATIVESsuppuratives n. Plural of suppurative.
SUPPURATIVE n. a suppurative agent.
UNPROPITIOUSunpropitious adj. Not propitious; unfavourable, untimely.
UNPROPITIOUS adj. not propitious.
UNPROSPEROUSunprosperous adj. Not prosperous.
UNPROSPEROUS adj. not prosperous.
UNSUPPORTIVEunsupportive adj. Not supportive.
UNSUPPRESSEDunsuppressed adj. Not suppressed.
UNSUPPRESSED adj. not suppressed.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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