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There are 17 eight-letter words containing 2P and 2U

MUDPUPPYmudpuppy n. An aquatic salamander of the family Proteidae.
mud␣puppy n. Alternative spelling of mudpuppy.
MUDPUPPY n. a large salamander, the axolotl.
OUTPUPILOUTPUPIL n. a student sent to a different school from the one he or she would normally attend.
PAPULOUSpapulous adj. Papulose.
PAPULOUS adj. having pimples, also PAPULOSE.
POPULOUSpopulous adj. Having a large population.
populous adj. (Of a language) Spoken by a large number of people.
populous adj. Densely populated.
PULPITUMpulpitum n. A massive, often decorative screen of stone or timber that divides the choir from the nave and ambulatory…
PULPITUM n. (Latin) a gigantic stone screen separating a cathedral choir from the nave.
PUPARIUMpuparium n. (Entomology) An enclosing case of a pupa that is formed from the exoskeleton of an insect’s final stage…
PUPARIUM n. (Latin) a pupal shell.
PUPPODUMpuppodum n. Rare spelling of papadam.
PUPPODUM n. (Tamil) a thin circle of dough fried in oil until crisp, also PAPADAM, PAPADOM, PAPADUM, PAPPADAM, PAPPADOM, PAPPADUM, POPADUM, POPPADOM, POPPADUM.
PUPUNHASpupunhas n. Plural of pupunha.
PUPUNHA n. (Portuguese) the peach-palm.
PURPURASpurpuras n. Plural of purpura.
Purpuras prop.n. Plural of Purpura.
PURPURA n. (Latin) a disease characterised by purple spots on the skin.
PURPURESPURPURE n. the heraldic colour purple.
PURPURICpurpuric adj. (Medicine) Pertaining to or affected with purpura (skin discoloration from blood inside it).
purpuric adj. (Medicine, archaic) Purple or purplish (of spots which appear on the skin; regardless of their cause);…
purpuric adj. (Chemistry, not comparable) purple in colour; derived from or forming a substance which is purple; especially…
PURPURINpurpurin n. A red anthraquinone dye, extracted from madder, that is used as a biological stain.
purpurin n. (Biochemistry) A protein of the lipocalin family.
purpurin n. (Historical) A brownish or deep red decorative glass used in ancient times.
SCUPPAUGscuppaug n. A fish: the scup.
SCUPPAUG n. (Native American) a marine fish food, also SCUP.
SEPPUKUSseppukus n. Plural of seppuku.
SEPPUKU n. (Japanese) a form of ritual suicide by cutting open the stomach.
UNSUPPLEunsupple adj. Not supple.
UNSUPPLE adj. not supple.
UPPERCUTuppercut n. (Boxing) A swinging blow aimed upwards at the opponent’s chin.
uppercut n. (Cricket) A cut shot that sends the ball over the wicket-keeper’s head.
uppercut v. To strike with an uppercut.
UPSPRUNGupsprung v. Simple past tense and past participle of upspring.
UPSPRING v. to spring up.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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