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There are 18 twelve-letter words containing P and 3U

ACUPUNCTURALacupunctural adj. Relating to acupuncture.
ACUPUNCTURAL adj. relating to acupuncture.
ACUPUNCTURESacupunctures n. Plural of acupuncture.
acupunctures v. Third-person singular simple present indicative form of acupuncture.
ACUPUNCTURE n. the complementary therapy of puncturing the skin with needles at specified points in order to cure illness.
CREPUSCULOUScrepusculous adj. Alternative form of crepuscular.
CREPUSCULOUS adj. relating to twilight, also CREPUSCULAR.
CUPULIFEROUScupuliferous adj. (Botany) Bearing, or furnished with, a cupule.
CUPULIFEROUS adj. bearing cupules.
GROUPUSCULESgroupuscules n. Plural of groupuscule.
GROUPUSCULE n. a small clique or faction.
MUCOPURULENTmucopurulent adj. (Medicine) Characterized by mucus and pus.
MUCOPURULENT adj. containing a mixture of mucus and pus.
PLUMULACEOUSplumulaceous adj. (Zoology, ornithology) Downy; bearing down.
PLUMULACEOUS adj. of or like plumulae, little feathers.
PRESUMPTUOUSpresumptuous adj. Going beyond what is right, proper, or appropriate because of an excess of self-confidence or arrogance.
PRESUMPTUOUS adj. overstepping due bounds (as of propriety or courtesy).
SCRUPULOUSLYscrupulously adv. In a careful manner, with scruple; done with careful attention to detail.
SCRUPULOUS adv. having moral integrity, acting in strict regard for what is considered right or proper.
SUBOPERCULUMsuboperculum n. (Anatomy) The lower opercular bone in fishes.
SUBOPERCULUM n. in fishes, a bone below and partly behind the gill cover.
SULPHUROUSLYsulphurously adv. Alternative spelling of sulfurously.
SULPHUROUS adv. containing sulphur in lower valency; pertaining to hellfire, also SULFUROUS.
SUPERNACULUMsupernaculum adv. (Obsolete) According to the rules of an old drinking game in which the drinker upturned the empty cup…
supernaculum adv. To the last drop, to the bottom.
supernaculum n. (Obsolete) Excellent wine that one would wish to drink to the last drop.
UNAUSPICIOUSunauspicious adj. Inauspicious.
UNAUSPICIOUS adj. (Shakespeare) inauspicious.
UNPUNCTUATEDunpunctuated adj. Not punctuated, lacking punctuation.
unpunctuated v. Simple past tense and past participle of unpunctuate.
UNPUNCTUATED adj. not punctuated.
UNSCRUPULOUSunscrupulous adj. Without scruples; immoral.
unscrupulous adj. Contemptuous of what is right or honorable.
UNSCRUPULOUS adj. not scrupulous.
UNSCULPTUREDunsculptured adj. Not sculptured.
UNSCULPTURED adj. not sculptured.
UNSUSPICIOUSunsuspicious adj. Not suspicious; not suspecting, unaware (of something).
unsuspicious adj. Not arousing suspicion.
UNSUSPICIOUS adj. not suspicious.
VOLUPTUOUSLYvoluptuously adv. In a voluptuous manner.
VOLUPTUOUS adv. given up to luxury; sensuous.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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