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There are 13 twelve-letter words containing O, 2S, 2T and 2U

AUSCULTATORSauscultators n. Plural of auscultator.
AUSCULTATOR n. a person practising auscultation.
AUTOSUGGESTSautosuggests v. Third-person singular simple present indicative form of autosuggest.
AUTOSUGGEST v. to influence one's own actions by self-suggestion.
BUTTONBUSHESbuttonbushes n. Plural of buttonbush.
BUTTONBUSH n. a North American shrub of the madder family with globular flower heads.
COUNTERSUITScountersuits n. Plural of countersuit.
COUNTERSUIT n. a suit in retaliation.
DISPUTATIOUSdisputatious adj. Of or relating to something that is in question as to its intent or value.
disputatious adj. Inclined to argue or debate; provoking debate.
DISPUTATIOUS adj. inclined to dispute.
POSTSTIMULUSpoststimulus adj. Following a stimulus.
POSTSTIMULUS adj. following on a stimulus.
PUSTULATIONSpustulations n. Plural of pustulation.
PUSTULATION n. the state of having pustules.
SUBSTITUTIONsubstitution n. The act of substituting or the state of being substituted.
substitution n. A substitute or replacement.
substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another.
SUBSTRUCTIONsubstruction n. (Architecture) underbuilding; the foundation, or any preliminary structure intended to raise the lower…
SUBSTRUCTION n. an underlying structure.
TESTUDINEOUStestudineous adj. Characteristic of a tortoise, or the shell of a tortoise.
testudineous adj. As slow as a tortoise.
TESTUDINEOUS adj. like a tortoiseshell or testudo, also TESTUDINAL, TESTUDINARY.
TORTUOUSNESStortuousness n. The property of being tortuous.
TORTUOUSNESS n. the state of being tortuous.
TUMULOSITIEStumulosities n. Plural of tumulosity.
TUMULOSITY n. the state of being tumulose, full of small hills or mounds.
UNCTUOSITIESunctuosities n. Plural of unctuosity.
UNCTUOSITY n. the state of being unctuous.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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