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There are 3 twelve-letter words containing 4O, P and 2T

OPISTHOTONOSopisthotonos n. (Medicine) Sustained tetanic spasm in which the body is bent backwards and stiffened, as produced by various diseases.
OPISTHOTONOS n. extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region, etc.
ORTHOTROPOUSorthotropous adj. (Botany, of an ovule) Growing straight and having the micropyle at the apex.
ORTHOTROPOUS adj. growing straight, so that the micropyle is opposite the stalk.
OSTEOPOROTICosteoporotic adj. Relating to osteoporosis.
OSTEOPOROTIC adj. relating to osteoporosis.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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