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There are 4 twelve-letter words containing O, 3T and 2U

AUTODESTRUCTautodestruct v. (Intransitive, chiefly science fiction) To destroy itself by design (as of a mechanical system).
autodestruct n. (Chiefly science fiction) A feature of a system whereby it destroys itself.
AUTODESTRUCT v. to self-destruct.
OUTTHRUSTINGoutthrusting v. Present participle of outthrust.
OUTTHRUST v. to extend outwards.
SUBSTITUTIONsubstitution n. The act of substituting or the state of being substituted.
substitution n. A substitute or replacement.
substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another.
TUMULTUATIONtumultuation n. (Obsolete) Irregular or disorderly movement; commotion.
TUMULTUATION n. (archaic) a tumult.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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