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There are 20 twelve-letter words containing 4O, P and S

COLONOSCOPEScolonoscopes n. Plural of colonoscope.
COLONOSCOPE n. a flexible viewing instrument passed into the colon through the anus.
HOMOEOMORPHShomœomorphs n. Plural of homœomorph.
HOMOEOMORPH n. a thing similar in form from another but essentially different, also HOMEOMORPH.
HOMOMORPHOUShomomorphous adj. Characterized by homomorphism.
HOMOMORPHOUS adj. alike in form, esp. if essentially different otherwise.
MONOMORPHOUSmonomorphous adj. Monomorphic.
MONOMORPHOUS adj. existing in one form only.
NONPOISONOUSnonpoisonous adj. Not poisonous.
non-poisonous adj. Alternative spelling of nonpoisonous.
NONPOISONOUS adj. not poisonous.
ODONTOPHORESodontophores n. Plural of odontophore.
ODONTOPHORE n. the rasping apparatus in molluscs.
OMBROPHOBOUSombrophobous adj. Synonym of ombrophobic.
OMBROPHOBOUS adj. of or like an ombrophobe, a plant thriving only in desert conditions.
OPISTHODOMOIopisthodomoi n. Plural of opisthodomos.
OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
OPISTHODOMOSopisthodomos n. (Greek architecture) A porch at the rear of a temple, set against the blank back wall of the cella.
OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
OPISTHOTONOSopisthotonos n. (Medicine) Sustained tetanic spasm in which the body is bent backwards and stiffened, as produced by various diseases.
OPISTHOTONOS n. extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region, etc.
ORTHOTROPOUSorthotropous adj. (Botany, of an ovule) Growing straight and having the micropyle at the apex.
ORTHOTROPOUS adj. growing straight, so that the micropyle is opposite the stalk.
OSTEOPOROSESosteoporoses n. Plural of osteoporosis.
OSTEOPOROSIS n. development of a porous structure in bone due to loss of calcium, resulting in brittleness.
OSTEOPOROSISosteoporosis n. (Pathology) A disease, occurring especially in women following menopause, in which the bones become…
OSTEOPOROSIS n. development of a porous structure in bone due to loss of calcium, resulting in brittleness.
OSTEOPOROTICosteoporotic adj. Relating to osteoporosis.
OSTEOPOROTIC adj. relating to osteoporosis.
PHOTOCOMPOSEphotocompose v. To use photocomposition to prepare text for printing.
PHOTOCOMPOSE v. to set (as reading matter) by photocomposition.
PODOCONIOSESPODOCONIOSIS n. endemic elephantiasis of the lower legs.
PODOCONIOSISpodoconiosis n. (Pathology) An endemic form of nonfilarial elephantiasis.
PODOCONIOSIS n. endemic elephantiasis of the lower legs.
POGONOTOMIESPOGONOTOMY n. shaving.
PROSOPOPOEIAprosopopoeia n. (Rhetoric) An act of personifying a person or object when communicating to an audience; a figure of…
prosopopoeia n. Personification of an abstraction.
prosopopœia n. Obsolete typography of prosopopoeia.
SPOROPHOROUSsporophorous adj. Relating to sporophores.
sporophorous adj. Having spores.
SPOROPHOROUS adj. bearing spores, also SPOROPHORIC.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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