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There are 4 eight-letter words containing 2O, P, R and X

EXOSPOREexospore n. The outer layer of a spore, especially in some algae and fungi.
EXOSPORE n. the outer covering of a spore.
HORSEPOXhorsepox n. A disease of horses caused by an orthopoxvirus.
horse-pox n. Alternative form of horsepox.
HORSEPOX n. a skin disease of horses.
OXYTROPEoxytrope n. (Botany) Synonym of locoweed.
OXYTROPE n. a genus of plants in the legume family, including locoweed.
PROTOXIDprotoxid n. Archaic form of protoxide.
PROTOXID n. that one of a series of oxides having the lowest proportion of oxygen, also PROTOXIDE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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