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There are 12 words containing N, O, 2P, 2S and 2U

POPULOUSNESSpopulousness n. The quality of being populous.
POPULOUSNESS n. the state of being populous.
SUPPURATIONSsuppurations n. Plural of suppuration.
SUPPURATION n. the discharge of pus.
UNPROSPEROUSunprosperous adj. Not prosperous.
UNPROSPEROUS adj. not prosperous.
UNSUPPOSABLEunsupposable adj. Not supposable; beyond imagining.
UNSUPPOSABLE adj. not supposable.
IMMUNOSUPPRESSimmunosuppress v. (Transitive) To cause immunosuppression in.
IMMUNOSUPPRESS v. to inhibit the body's immune response.
POPULOUSNESSESPOPULOUSNESS n. the state of being populous.
PURPOSEFULNESSpurposefulness n. The state of being purposeful.
PURPOSEFUL n. showing purpose.
SUBPOPULATIONSsubpopulations n. Plural of subpopulation.
SUBPOPULATION n. an identifiable fraction or subdivision of a population.
UNPRESUMPTUOUSunpresumptuous adj. Not presumptuous; modest.
UNPRESUMPTUOUS adj. not presumptuous.
UNPROSPEROUSLYunprosperously adv. In an unprosperous manner.
UNPROSPEROUS adv. not prosperous.
PERSPICUOUSNESSperspicuousness n. The state or characteristic of being perspicuous; perspicuity.
PERSPICUOUSNESS n. the state of being perspicuous.
SUPERCOMPUTINGSSUPERCOMPUTING n. computing using a supercomputer, a large very fast mainframe used esp. for scientific computations.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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See this list for:

  • English Wiktionary: 170 words
  • Scrabble in French: 16 words
  • Scrabble in Spanish: 7 words
  • Scrabble in Italian: no word
  • Scrabble in German: no word
  • Scrabble in Romanian: no word


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