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There are 20 twelve-letter words containing N, 2S, 2T and 2U

BUTTONBUSHESbuttonbushes n. Plural of buttonbush.
BUTTONBUSH n. a North American shrub of the madder family with globular flower heads.
COUNTERSUITScountersuits n. Plural of countersuit.
COUNTERSUIT n. a suit in retaliation.
GUTTURALNESSgutturalness n. The quality of being guttural.
GUTTURALNESS n. the state of being guttural.
INTUSSUSCEPTintussuscept v. (Medicine, transitive, intransitive) To cause or undergo intussusception.
INTUSSUSCEPT v. to take in by or cause to undergo intussusception.
PUNCTUALISTSpunctualists n. Plural of punctualist.
PUNCTUALIST n. (obsolete) an authority on or observer of punctilios.
PUSTULATIONSpustulations n. Plural of pustulation.
PUSTULATION n. the state of having pustules.
SUBSTITUENTSsubstituents n. Plural of substituent.
SUBSTITUENT n. a thing, esp. an atom, substituted for another.
SUBSTITUTINGsubstituting v. Present participle of substitute.
SUBSTITUTE v. to put or use in the place of another.
SUBSTITUTIONsubstitution n. The act of substituting or the state of being substituted.
substitution n. A substitute or replacement.
substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another.
SUBSTRUCTINGsubstructing v. Present participle of substruct.
SUBSTRUCT v. to build beneath; to lay as a foundation.
SUBSTRUCTIONsubstruction n. (Architecture) underbuilding; the foundation, or any preliminary structure intended to raise the lower…
SUBSTRUCTION n. an underlying structure.
SUSTENTACULAsustentacula n. Plural of sustentaculum.
SUSTENTACULUM n. a supporting part or structure.
TESTUDINEOUStestudineous adj. Characteristic of a tortoise, or the shell of a tortoise.
testudineous adj. As slow as a tortoise.
TESTUDINEOUS adj. like a tortoiseshell or testudo, also TESTUDINAL, TESTUDINARY.
TORTUOUSNESStortuousness n. The property of being tortuous.
TORTUOUSNESS n. the state of being tortuous.
TRUSTBUSTINGtrustbusting n. (US) The breaking up of trusts or monopolies.
TRUSTBUSTING n. the dissolution of corporate trusts.
TRUSTFULNESStrustfulness n. The property of being trustful.
TRUSTFULNESS n. the state of being trustful.
TRUTHFULNESStruthfulness n. The quality of being truthful.
TRUTHFULNESS n. the state of being truthful.
UNCTUOSITIESunctuosities n. Plural of unctuosity.
UNCTUOSITY n. the state of being unctuous.
UNDERTHRUSTSunderthrusts v. Third-person singular simple present indicative form of underthrust.
UNDERTHRUST v. to insert (a faulted rock mass) into position under a passive rock mass.
UNTRUSTINESSuntrustiness n. The state or quality of being untrusty.
UNTRUSTINESS n. (obsolete) the state of being untrusty.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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