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There are 14 twelve-letter words containing N, 2O, 2P and U

DEPOPULATIONdepopulation n. The act of depopulating or condition of being depopulated; the destruction or expulsion of inhabitants.
DEPOPULATION n. the act of depopulating.
NONPURPOSIVEnonpurposive adj. Not purposive.
NONPURPOSIVE adj. not purposive.
OPPORTUNISMSopportunisms n. Plural of opportunism.
OPPORTUNISM n. the practice of regulating actions by favourable opportunities rather than consistent principles.
OPPORTUNISTSopportunists n. Plural of opportunist.
OPPORTUNIST n. one that is opportunistic or that practices opportunism.
OUTCROPPINGSoutcroppings n. Plural of outcropping.
OUTCROPPING n. an outcrop.
PANTOPHAGOUSpantophagous adj. Eating all kinds of food.
PANTOPHAGOUS adj. eating or requiring a variety of foods.
PHOSPHONIUMSphosphoniums n. Plural of phosphonium.
PHOSPHONIUM n. the radical PH4, analogous to ammonium.
POPULATIONALpopulational adj. Of or pertaining to population.
POPULATIONAL adj. relating to population.
POPULOUSNESSpopulousness n. The quality of being populous.
POPULOUSNESS n. the state of being populous.
PROPUGNATIONpropugnation n. (Obsolete) means of defence; defence.
PROPUGNATION n. (Shakespeare) defence.
REPOPULATIONrepopulation n. The act of repopulating, especially with a species that might otherwise die out in an area.
REPOPULATION n. the act of repopulating.
SUPPOSITIONSsuppositions n. Plural of supposition.
SUPPOSITION n. something that is supposed.
UNPROPITIOUSunpropitious adj. Not propitious; unfavourable, untimely.
UNPROPITIOUS adj. not propitious.
UNPROSPEROUSunprosperous adj. Not prosperous.
UNPROSPEROUS adj. not prosperous.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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