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There are 15 ten-letter words containing N, 2O, 2P and U

BUPROPIONSBUPROPION n. an antidepressant drug used in the treatment of nicotine addiction.
DOUPPIONISdouppionis n. Plural of douppioni.
DOUPPIONI n. a kind of silk yarn, also DOUPIONI, DUPION.
NICKUMPOOPnickumpoop n. Obsolete spelling of nincompoop.
NICKUMPOOP n. a fool; a silly or stupid person, also NICOMPOOP, NINCOMPOOP.
NONPOPULARnonpopular adj. Not popular.
NONPOPULAR adj. not popular.
NONSUPPORTnonsupport n. (Uncountable)A lack of support.
nonsupport n. (Uncountable)The failure to provide for one’s family or other dependents.
nonsupport n. (Countable) One who fails to provide support.
OUTTOPPINGouttopping v. Present participle of outtop.
out-topping v. Present participle of out-top.
OUTTOP v. to overtop.
POPULATIONpopulation n. The people living within a political or geographical boundary.
population n. (By extension) The people with a given characteristic.
population n. A count of the number of residents within a political or geographical boundary such as a town, a nation or the world.
POURPOINTSpourpoints n. Plural of pourpoint.
POURPOINT n. (French) a mediaeval quilted doublet.
PROPOUNDEDpropounded v. Simple past tense and past participle of propound.
PROPOUND v. to propose.
PROPOUNDERpropounder n. One who propounds.
PROPOUNDER n. one who propounds.
PROPULSIONpropulsion n. The action of driving or pushing, typically forward or onward; a propulsive force or impulse.
PROPULSION n. the act of propelling.
SOUPSPOONSsoupspoons n. Plural of soupspoon.
soup␣spoons n. Plural of soup spoon.
SOUPSPOON n. a spoon for eating soup.
UNOPPOSINGunopposing adj. Not offering opposition; unresisting.
UNOPPOSING adj. not opposing.
UNPOPULOUSunpopulous adj. Not populous; having a small population.
UNPOPULOUS adj. not populous.
UNPROPOSEDunproposed adj. Not having been proposed.
UNPROPOSED adj. not proposed.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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