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There are 8 eight-letter words containing 2N, S and X

DISANNEXdisannex v. (Transitive) To relinquish (Land etc.) previously annexed.
DISANNEX v. to disunite; to undo or repeal the annexation of.
MONAXONSmonaxons n. Plural of monaxon.
MONAXON n. a straight spicule in sponges.
NEXTNESSnextness n. The fact or condition of immediate succession or proximity; the quality of being next.
NEXTNESS n. the state of being next.
NONTAXESnontaxes n. Plural of nontax.
NONTAX n. a tax of little consequence.
SIXPENNYsixpenny adj. Worth six pennies.
sixpenny adj. (Dated) Cheap; worthless.
sixpenny n. A publication costing sixpence.
UNSEXINGunsexing v. Present participle of unsex.
UNSEX v. to deprive of sexual power.
XANTHANSxanthans n. Plural of xanthan.
XANTHAN n. a gum produced by culture fermentation of glucose, used as a stabilizer, also XANTHAM.
XANTHINSxanthins n. Plural of xanthin.
XANTHIN n. a white substance, structurally related to uric acid, found in muscle tissue, the liver and other organs, also XANTHINE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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