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There are 15 twelve-letter words containing M, 2O, 2P and U

AMPHITROPOUSamphitropous adj. (Botany) Having the ovule bent so that the ends are near each other.
AMPHITROPOUS adj. of an ovule, with its point of attachment in the middle.
HIPPOPOTAMUShippopotamus n. A large, semi-aquatic, herbivorous (plant-eating) African mammal (Hippopotamus amphibius; common hippopotamus).
hippopotamus n. Any similar animal of the family Hippopotamidae.
Hippopotamus prop.n. A taxonomic genus within the family Hippopotamidae – hippopotamuses.
OPPORTUNISMSopportunisms n. Plural of opportunism.
OPPORTUNISM n. the practice of regulating actions by favourable opportunities rather than consistent principles.
PARAMORPHOUSparamorphous adj. (Mineralogy) Relating to, or exhibiting, paramorphism.
PARAMORPHOUS adj. of or like a paramorph.
PERIMORPHOUSperimorphous adj. Perimorphic.
PERIMORPHOUS adj. like a perimorph, also PERIMORPHIC.
PHOSPHONIUMSphosphoniums n. Plural of phosphonium.
PHOSPHONIUM n. the radical PH4, analogous to ammonium.
PITTOSPORUMSpittosporums n. Plural of pittosporum.
PITTOSPORUM n. any of numerous chiefly subtropical evergreen shrubs or small trees.
PITYROSPORUMPityrosporum prop.n. Former name of Malassezia (“fungus genus”).
PITYROSPORUM n. a yeastlike fungus which can cause pityriasis.
PLEOMORPHOUSpleomorphous adj. Having or passing through many different forms.
PLEOMORPHOUS adj. occurring in several different forms, also PLEOMORPHIC.
PODOPHYLLUMSpodophyllums n. Plural of podophyllum.
PODOPHYLLUM n. the dried rootlet and rhizome of the mayapple, used as a caustic.
POLYMORPHOUSpolymorphous adj. Having, or assuming, a variety of forms, characters, or styles.
polymorphous adj. (Biology) Having, or occurring in, several distinct forms.
polymorphous adj. (Chemistry) Crystallizing in two or more different forms; polymorphic.
POMPELMOUSESpompelmouses n. Plural of pompelmous.
pompelmouses n. Plural of pompelmouse.
POMPELMOUSE n. (Dutch) the shaddock or grapefruit, also PAMPELMOOSE, PAMPELMOUSE, POMELO, POMPELMOOSE, POMPELMOUS, POMPELO, PUMELO, PUMMELO.
POMPHOLYGOUSPOMPHOLYGOUS adj. of or like a pompholyx, a vesicular eruption or eczema chiefly on the palms and soles.
PSEUDOMORPHSpseudomorphs n. Plural of pseudomorph.
PSEUDOMORPH n. a false or abnormal physical form.
PSEUDOPODIUMpseudopodium n. (Cytology) pseudopod.
PSEUDOPODIUM n. a process protruding from the cell of a protozoan, etc., used for movement or feeding.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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