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There are 20 ten-letter words containing M, R, 2S and 2U

AUTEURISMSAUTEURISM n. the profession of auteur, film director.
BUMSUCKERSbumsuckers n. Plural of bumsucker.
BUMSUCKER n. (slang) a toady.
CASSUMUNARcassumunar n. A pungent, bitter, aromatic root, Zingiber montanum, resembling ginger, obtained from the East Indies.
CASSUMUNAR n. an aromatic root similar to ginger.
DISHUMOURSdishumours v. Third-person singular simple present indicative form of dishumour.
DISHUMOUR v. (obsolete) to put out of humour.
EREMURUSESeremuruses n. Plural of eremurus.
EREMURUS n. (Latin) a flower, the foxtail lily.
GUMSUCKERSGUMSUCKER n. (Australian slang) a native-born Australian.
HUMOURLESShumourless adj. (British spelling, Canada) Alternative spelling of humorless.
HUMOURLESS adj. without humour, also HUMORLESS.
LIGUSTRUMSligustrums n. Plural of ligustrum.
LIGUSTRUM n. a plant of a genus that comprises the privets.
MENSTRUOUSmenstruous adj. Of or pertaining to menstruation; menstrual.
menstruous adj. (Of a female) Currently undergoing menstruation.
menstruous adj. (Obsolete) Monthly.
MENSTRUUMSmenstruums n. Plural of menstruum.
MENSTRUUM n. (Latin) a solvent, esp. one used in the preparation of drugs.
MONSTRUOUSmonstruous adj. (Now rare) Monstrous.
MONSTRUOUS adj. (obsolete) monstrous.
MOSASAURUSMosasaurus prop.n. A taxonomic genus within the family Mosasauridae – a mosasaur from the Late Cretaceous of Europe, North…
MOSASAURUS n. a gigantic Cretaceous fossil pythonomorph reptile, also MOSASAUR.
SEQUESTRUMsequestrum n. A fragment of bone or other dead tissue that has separated during necrosis.
SEQUESTRUM n. (Latin) a portion of dead bone which becomes separated from the sound portion, as in necrosis.
SLUMBEROUSslumberous adj. Sleepy, drowsy.
slumberous adj. Sleep-inducing.
SLUMBEROUS adj. inviting or causing slumber, also SLUMBERY, SLUMBROUS, SLUMBRY.
SUBSTRATUMsubstratum n. A layer that lies underneath another.
substratum n. (Figuratively) The underlying cause or basis of something.
substratum n. (Linguistics) A substrate.
SUCCUMBERSsuccumbers n. Plural of succumber.
SUCCUMBER n. one who succumbs.
SUGARPLUMSsugarplums n. Plural of sugarplum.
sugar-plums n. Plural of sugar-plum.
sugar␣plums n. Plural of sugar plum.
SURMULLETSsurmullets n. Plural of surmullet.
SURMULLET n. a fish much esteemed by the Romans for its dramatic color changes as it died.
UNSURMISEDunsurmised adj. Not surmised.
UNSURMISED adj. not surmised.
VULTURISMSvulturisms n. Plural of vulturism.
VULTURISM n. (Carlyle) the state of being like a vulture; rapacity.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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