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There are 15 eight-letter words containing M, P, S and 2U

EUPHUISMeuphuism n. (Uncountable) An ornate style of writing (in Elizabethan England) marked by the excessive use of alliteration…
euphuism n. An instance of euphuism.
EUPHUISM n. an affected literary style.
JUMPSUITjumpsuit n. A one-piece item of clothing originally used by parachutists.
jumpsuit n. A similar item of clothing used for outdoor sports such as skiing.
jump␣suit n. Alternative form of jumpsuit.
MUGWUMPSmugwumps n. Plural of mugwump.
mugwumps v. Third-person singular simple present indicative form of mugwump.
MUGWUMP n. (Native American) a bolter from the Republican party in 1884; a political independent.
OUTJUMPSoutjumps v. Third-person singular simple present indicative form of outjump.
OUTJUMP v. to surpass in jumping.
PABULUMSpabulums n. Plural of pabulum.
PABULUM n. (Latin) food, esp. a suspension or solution of nutrients in a state suitable for absorption; something (as writing or speech) that is insipid, simplistic, or bland, also PABLUM.
PLUMBOUSplumbous adj. (Chemistry) Of, pertaining to, resembling or containing lead.
plumbous adj. (Chemistry) Specifically, of compounds in which it has a lower valence as contrasted with plumbic compounds.
PLUMBOUS adj. containing lead.
PLUMBUMSPLUMBUM n. (obsolete) lead.
PLUMULESplumules n. Plural of plumule.
PLUMULE n. the embryo shoot in a seed, also PLUMULA.
PUNCTUMSpunctums n. Plural of punctum.
PUNCTUM n. (Latin) a point or dot; a minute aperture.
RUMPUSESrumpuses n. Plural of rumpus.
RUMPUS n. a noisy disturbance.
SPECULUMspeculum n. (Medicine) A medical instrument used during an examination to dilate an orifice.
speculum n. A mirror, especially one used in a telescope.
speculum n. (Ornithology) A bright, lustrous patch of colour found on the wings of ducks and some other birds, usually…
SPICULUMspiculum n. A thrusting javelin used by Romans that replaced the pilum in the late 3rd century.
spiculum n. A sharp, pointed crystal, especially of ice.
spiculum n. (Zoology) A sharp, needle-like structure, especially those making up the skeleton of a sponge.
SUPREMUMsupremum n. (Set theory) (real analysis): Given a subset X of R, the smallest real number that is ≥ every element…
SUPREMUM n. in maths, a maximum bound.
UNPLUMBSunplumbs v. Third-person singular simple present indicative form of unplumb.
UNPLUMB v. to remove lead from.
UNPLUMESunplumes v. Third-person singular simple present indicative form of unplume.
UNPLUME v. to strip of feathers.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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