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There are 9 twelve-letter words containing 2M, S and X

AXISYMMETRICaxisymmetric adj. Exhibiting symmetry around an axis; exhibiting cylindrical symmetry.
axi-symmetric adj. Alternative form of axisymmetric.
AXISYMMETRIC adj. symmetrical in respect to an axis, also AXISYMMETRICAL.
EXCOMMUNIONSEXCOMMUNION n. (Milton) excommunication.
IMMUNOTOXINSimmunotoxins n. Plural of immunotoxin.
IMMUNOTOXIN n. a toxin with immunosuppressive effects.
MAXIMISATIONmaximisation n. Alternative spelling of maximization.
MAXIMISATION n. the act of maximising, also MAXIMATION, MAXIMIZATION.
MYXEDEMATOUSmyxedematous adj. Relating to, or exhibiting, myxedema.
MYXEDEMATOUS adj. (US) relating to myxedema, a skin disease, also MYXOEDEMATOUS.
MYXOMYCETOUSmyxomycetous adj. Relating to the fungus class Myxomycetes.
MYXOMYCETOUS adj. of or like a myxomycete, a slime mould.
SUBMAXIMALLYsubmaximally adv. In a submaximal manner; less than maximally.
XERANTHEMUMSxeranthemums n. Plural of xeranthemum.
XERANTHEMUM n. any plant of the Xeranthemum genus of plants of southern Europe, belonging to the thistle family.
XYLOBALSAMUMxylobalsamum n. The dried twigs or fragrant wood of balm of Gilead (or balsam of Mecca).
XYLOBALSAMUM n. the dried twigs, or the wood, of the balm of Gilead tree.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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