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There are 10 four-letter words containing M and 2S

ISMSisms n. Plural of ism.
ISMs n. Plural of ISM.
ISMS n. Initialism of information security management system.
MASSmass n. (Physical) Matter, material.
mass n. A large quantity; a sum.
mass v. (Transitive) To form or collect into a mass; to form into a collective body; to bring together into…
MESSmess n. A disagreeable mixture or confusion of things; hence, a situation resulting from blundering or from misunderstanding.
mess n. (Colloquial) A large quantity or number.
mess n. (Euphemistic) Excrement.
MISSmiss v. (Transitive, intransitive) To fail to hit.
miss v. (Transitive) To fail to achieve or attain.
miss v. (Transitive) To avoid; to escape.
MOSSmoss n. Any of various small, green, seedless plants growing on the ground or on the surfaces of trees, stones…
moss n. (Countable) A kind or species of such plants.
moss n. (Informal) Any alga, lichen, bryophyte, or other plant of seemingly simple structure.
MUSSmuss v. (Transitive) To rumple, tousle or make (something) untidy.
muss n. A mess (disagreeable mixture or confusion of things; disorder).
muss n. (Obsolete) A scramble, as when small objects are thrown down, to be taken by those who can seize them;…
SAMSsams n. Plural of sam.
Sams prop.n. Plural of Sam.
Sams prop.n. A diminutive of the female given name Samantha, variant of Sam.
SIMSsims n. Plural of sim.
Sims prop.n. A surname transferred from the given name.
Sims n. Plural of Sim.
SOMSsoms n. Plural of som.
Soms prop.n. Plural of Som.
SOM n. a monetary unit of Kyrgyzstan.
SUMSsums n. Plural of sum.
sums v. Third-person singular simple present indicative form of sum.
Sums prop.n. Plural of Sum.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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