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There are 4 twelve-letter words containing L, O, R, 2S, T and X

EXTRASYSTOLEextrasystole n. (Medicine) A premature contraction of the heart, producing an interruption or irregularity in heartbeat…
EXTRASYSTOLE n. a premature beat of one of the chambers of the heart that leads to momentary arrhythmia.
METROSEXUALSmetrosexuals n. Plural of metrosexual.
METROSEXUAL n. a heterosexual man who spends a lot of time and money on his appearance and likes to shop.
RETROSEXUALSretrosexuals n. Plural of retrosexual.
RETROSEXUAL n. a man with traditional sexual attitudes.
SPORTSPLEXESsportsplexes n. Plural of sportsplex.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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