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There are 9 words containing I, R, 2S and 4T

LITHOTRITISTSlithotritists n. Plural of lithotritist.
LITHOTRITIST n. one who performs a lithotrity.
LITHOTRIPTISTSlithotriptists n. Plural of lithotriptist.
LITHOTRIPTIST n. a surgeon who performs a lithotripsy.
RESTITUTIONISTRESTITUTIONIST n. a believer in restitutionism.
TRISUBSTITUTEDtrisubstituted adj. (Organic chemistry) substituted with three (identical or different) substituents.
TRISUBSTITUTED adj. having three substituent atoms or groups in the molecule.
TRUSTWORTHIESTtrustworthiest adj. Superlative form of trustworthy: most trustworthy.
TRUSTWORTHY adj. worthy of confidence.
LITHONTRIPTISTSlithontriptists n. Plural of lithontriptist.
LITHONTRIPTIST n. a surgeon who performs a lithotripsy.
QUATTROCENTISTSquattrocentists n. Plural of quattrocentist.
QUATTROCENTIST n. an artist who flourished in the fifteenth century in reference to Italian art and literature.
RESTITUTIONISTSRESTITUTIONIST n. a believer in restitutionism.
STRAITWAISTCOATstraitwaistcoat n. (Now rare) A straitjacket.
STRAITWAISTCOAT n. a straitjacket.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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