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There are 9 words containing I, R, 2S and 4T

LITHONTRIPTISTSlithontriptists n. Plural of lithontriptist.
LITHONTRIPTIST n. a surgeon who performs a lithotripsy.
LITHOTRIPTISTSlithotriptists n. Plural of lithotriptist.
LITHOTRIPTIST n. a surgeon who performs a lithotripsy.
LITHOTRITISTSlithotritists n. Plural of lithotritist.
LITHOTRITIST n. one who performs a lithotrity.
QUATTROCENTISTSquattrocentists n. Plural of quattrocentist.
QUATTROCENTIST n. an artist who flourished in the fifteenth century in reference to Italian art and literature.
RESTITUTIONISTRESTITUTIONIST n. a believer in restitutionism.
RESTITUTIONISTSRESTITUTIONIST n. a believer in restitutionism.
STRAITWAISTCOATstraitwaistcoat n. (Now rare) A straitjacket.
STRAITWAISTCOAT n. a straitjacket.
TRISUBSTITUTEDtrisubstituted adj. (Organic chemistry) substituted with three (identical or different) substituents.
TRISUBSTITUTED adj. having three substituent atoms or groups in the molecule.
TRUSTWORTHIESTtrustworthiest adj. Superlative form of trustworthy: most trustworthy.
TRUSTWORTHY adj. worthy of confidence.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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