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There are 16 words containing I, 2P, 2S and 2U

HUSHPUPPIEShushpuppies n. Plural of hushpuppy.
hush␣puppies n. Plural of hush puppy.
HUSHPUPPY n. a snack of deep-fried cornmeal bread.
IMMUNOSUPPRESSimmunosuppress v. (Transitive) To cause immunosuppression in.
IMMUNOSUPPRESS v. to inhibit the body's immune response.
LIPOSCULPTURESLIPOSCULPTURE n. cosmetic surgery on the lips.
MULTIPURPOSESSorry, definition not available.
PERSPICUOUSperspicuous adj. Clearly expressed, easy to understand; lucid.
perspicuous adj. (Logic) Of a language or notation, such as that of formal propositional calculus: where the process…
perspicuous adj. (Rare) Transparent; translucent.
PERSPICUOUSLYperspicuously adv. With clarity and lucidity.
PERSPICUOUS adv. easily understood; clearly expressed.
PERSPICUOUSNESSperspicuousness n. The state or characteristic of being perspicuous; perspicuity.
PERSPICUOUSNESS n. the state of being perspicuous.
SUBPOPULATIONSsubpopulations n. Plural of subpopulation.
SUBPOPULATION n. an identifiable fraction or subdivision of a population.
SUPERCOMPUTINGSSUPERCOMPUTING n. computing using a supercomputer, a large very fast mainframe used esp. for scientific computations.
SUPERPREMIUMSsuperpremiums n. Plural of superpremium.
SUPERPREMIUM n. a very large premium.
SUPPOSITIOUSsuppositious adj. Spurious; substituted for the genuine, counterfeit; fake; supposititious.
suppositious adj. Imaginary; fictitious, pretended to exist.
suppositious adj. Hypothetical, based on supposition; suppositional.
SUPPOSITIOUSLYsuppositiously adv. In a suppositious manner.
SUPPOSITIOUS adv. fraudulently substituted, also SUPPOSITITIOUS.
SUPPOSITITIOUSsupposititious adj. (Obsolete) Spurious; substituted for the genuine, counterfeit; fake.
supposititious adj. (Obsolete) Imaginary; fictitious, pretended to exist.
supposititious adj. Supposed or hypothetical.
SUPPURATIONSsuppurations n. Plural of suppuration.
SUPPURATION n. the discharge of pus.
SUPPURATIVESsuppuratives n. Plural of suppurative.
SUPPURATIVE n. a suppurative agent.
UNDERSUPPLIESundersupplies v. Third-person singular simple present indicative form of undersupply.
UNDERSUPPLY v. to supply too little.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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