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There are 18 words containing I, 2O, 2R and 2U

UPROARIOUSuproarious adj. Causing, or likely to cause, an uproar.
uproarious adj. Characterized by uproar, that is, loud, confused noise, or by noisy and uncontrollable laughter.
uproarious adj. (By extension) Extremely funny; hilarious.
FRUGIVOROUSfrugivorous adj. Having a diet that consists mostly of fruit; fruit-eating.
FRUGIVOROUS adj. eating fruit.
FLUOROURACILfluorouracil n. (Pharmacology) A fluorine-substituted derivative of uracil C4H3FN2O2 which inhibits DNA synthesis and…
FLUOROURACIL n. a fluorine-containing pyrimidine base used as a neoplastic agent to treat some kinds of cancer.
FRUCTIVOROUSfructivorous adj. Fruit-eating.
FRUCTIVOROUS adj. feeding on fruit.
SUDORIFEROUSsudoriferous adj. Bearing sweat; sweating, sweaty.
SUDORIFEROUS adj. inducing or secreting sweat.
SUDORIPAROUSsudoriparous adj. Sudoriferous.
SUDORIPAROUS adj. secreting sweat.
UPROARIOUSLYuproariously adv. In an uproarious manner.
UPROARIOUS adv. marked by uproar.
FLUOROURACILSfluorouracils n. Plural of fluorouracil.
FLUOROURACIL n. a fluorine-containing pyrimidine base used as a neoplastic agent to treat some kinds of cancer.
SUPERVIRTUOSOsupervirtuoso n. A very talented or successful virtuoso.
SUPERVIRTUOSO n. an exceptionally talented virtuoso.
CIRCUMLOCUTORYcircumlocutory adj. Characterised by circumlocution; periphrastic; verbose.
CIRCUMLOCUTORY adj. relating to circumlocution.
CIRCUMVOLUTORYcircumvolutory adj. Exhibiting or relating to circumvolution.
CIRCUMVOLUTORY adj. winding around.
OUTREPRODUCINGoutreproducing v. Present participle of outreproduce.
OUTREPRODUCE v. to surpass in reproducing.
SUPERVIRTUOSOSsupervirtuosos n. Plural of supervirtuoso.
SUPERVIRTUOSO n. an exceptionally talented virtuoso.
UPROARIOUSNESSuproariousness n. Noisy riot or hilarity; uproar.
UPROARIOUSNESS n. the state of being uproarious.
CIRCUMFORANEOUScircumforaneous adj. Wandering from place to place or market to market.
circumforaneous adj. (By extension) Indirect, roundabout, or unnecessarily complex.
CIRCUMFORANEOUS adj. wandering about as from market to market, vagrant, also CIRCUMFORANEAN.
STROMBULIFEROUSSTROMBULIFEROUS adj. bearing spirally coiled organs.
UNDERPRODUCTIONunderproduction n. The production of an insufficient amount.
UNDERPRODUCTION n. the production of less than enough to satisfy the demand or of less than the usual amount.
UNREVOLUTIONARYunrevolutionary adj. Not revolutionary.
UNREVOLUTIONARY adj. not revolutionary.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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