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There are 13 words containing 2I, 4S and Y

SISSYISHsissyish adj. Like a sissy.
SISSYISH adj. resembling a sissy.
SYSSITIASsyssitias n. Plural of syssitia.
SYSSITIA n. (Greek) the ancient Spartan custom of eating the main meal together in public.
BYSSINOSISbyssinosis n. A lung disease, caused by exposure to cotton dust in inadequately ventilated working environments.
BYSSINOSIS n. cotton dust pneumoconiosis.
VICHYSSOISESvichyssoises n. Plural of vichyssoise.
VICHYSSOISE n. (French) a soup made with potatoes, leeks, and cream, and usually served cold.
DISSYLLABISMSDISSYLLABISM n. the fact of having two syllables.
HYPOSENSITISEShyposensitises v. Third-person singular simple present indicative form of hyposensitise.
HYPOSENSITISE v. to cause (a person) to become less sensitive to (a substance producing an allergic reaction), also HYPOSENSITIZE.
SYSTEMISATIONSsystemisations n. Plural of systemisation.
SYSTEMISATION n. the act of systemising, also SYSTEMIZATION.
ASTROPHYSICISTSastrophysicists n. Plural of astrophysicist.
ASTROPHYSICIST n. a student of astrophysics.
BIOSYSTEMATISTSbiosystematists n. Plural of biosystematist.
BIOSYSTEMATIST n. one who studies biosystematics.
COMMISSARYSHIPScommissaryships n. Plural of commissaryship.
COMMISSARYSHIP n. the office of commissary.
HYPERSENSITISEShypersensitises v. Third-person singular simple present indicative form of hypersensitise.
HYPERSENSITISE v. to make hypersensitive, also HYPERSENSITIZE.
IMMUNOASSAYISTSIMMUNOASSAYIST n. one who carries out immunoassays.
SYNTHESISATIONSSYNTHESISATION n. the process of synthesising, also SYNTHESIZATION.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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See this list for:

  • English Wiktionary: 139 words
  • Scrabble in French: 91 words
  • Scrabble in Spanish: 2 words
  • Scrabble in Italian: no word
  • Scrabble in German: no word
  • Scrabble in Romanian: no word


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