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There are 10 words containing 3I, O, 2P and U

PROPINQUITIESpropinquities n. Plural of propinquity.
PROPINQUITY n. nearness in space, time or relationship.
PROPITIATIOUSPROPITIATIOUS adj. serving to propitiate, also PROPITIATIVE, PROPITIATORY.
YUPPIFICATIONyuppification n. The act or process of yuppifying.
YUPPIFICATION n. the process of conversion into a yuppy.
SUPPOSITITIOUSsupposititious adj. (Obsolete) Spurious; substituted for the genuine, counterfeit; fake.
supposititious adj. (Obsolete) Imaginary; fictitious, pretended to exist.
supposititious adj. Supposed or hypothetical.
YUPPIFICATIONSYUPPIFICATION n. the process of conversion into a yuppy.
APPROPINQUITIESAPPROPINQUITY n. nearness.
HYPOPITUITARISMhypopituitarism n. (Medicine) A decrease in secretion of one or more of the eight hormones normally produced by the pituitary gland.
HYPOPITUITARISM n. deficient production of growth hormones by the pituitary gland.
INOPPORTUNITIESINOPPORTUNITY n. the state of being inopportune.
SUPERIMPOSITIONsuperimposition n. The process, or the result of superimposing.
superimposition n. The placing of one image on top of another, especially placing a photograph over some other graphic.
superimposition n. (Philosophy) The building of ontological categories of a higher level on top of categories of a lower level.
UNDISAPPOINTINGundisappointing adj. Not disappointing.
UNDISAPPOINTING adj. not disappointing.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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