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There are 4 nine-letter words containing 2I, O, 2R and 2S

CIRRHOSIScirrhosis n. (Pathology) A chronic disease of the liver caused by damage from toxins (including alcohol), metabolic…
cirrhosis n. (By extension) Interstitial inflammation of kidneys, lungs, and other organs.
CIRRHOSIS n. a disease of the liver caused by alcoholism.
IRRISIONSirrisions n. Plural of irrision.
IRRISION n. the act of laughing at another.
RIGORISMSrigorisms n. Plural of rigorism.
RIGORISM n. rigidity in principle or practice.
RIGORISTSrigorists n. Plural of rigorist.
RIGORIST n. one who professes rigorism.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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