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There are 3 eight-letter words containing 2I, O, R, S and 2T

AORTITISaortitis n. (Pathology) Inflammation of the aorta.
AORTITIS n. inflammation of the aorta.
INTROITSintroits n. Plural of introit.
INTROIT n. (Latin) psalm or antiphon sung or said at the start of a service.
TROILISTtroilist adj. Involving three sexual partners; pertaining to a threesome.
troilist n. A participant in a sexual threesome.
TROILIST n. one who engages in troilism, sexual activity between three people.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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