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There are 4 eight-letter words containing 2I, M, 2N, O and S

HOMININShominins n. Plural of hominin.
HOMININ n. any member of the taxonomic tribe Hominini, usually taken to comprise humans and their direct ancestors, but sometimes taken also to include chimpanzees.
INSOMNIAinsomnia n. (Medicine) A sleeping disorder that is known for its symptoms of unrest and the inability to sleep.
INSOMNIA n. chronic inability to sleep.
MISUNIONmisunion n. A bad or wrong union or alliance.
MISUNION n. a bad union.
UNIONISMunionism n. The support of advocacy of a union, especially of a trade union.
unionism n. (Often capitalised) Support for the North (the Union) during the American Civil War.
unionism n. (Often capitalised) Support for the continuance of the United Kingdom (especially with respect to Northern Ireland).

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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