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There are 3 eight-letter words containing 2I, L, O, P and 2S

DIPLOSISDIPLOSIS n. a method of chromosome formation.
PSILOSISpsilosis n. (Phonology) The sound change by which Greek lost the consonant sound /h/ during antiquity.
psilosis n. (Medicine) Sprue, a disease of the small intestine.
PSILOSIS n. (Greek) loss of hair.
PTILOSISptilosis n. (Ornithology) The appearance or study of feathers on a bird, including factors such as their texture or shape.
ptilosis n. (Medicine) Loss of the eyelashes, due to ulceration or other damage to the follicles.
PTILOSIS n. (Greek) plumage or mode of feathering.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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