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There are 8 fifteen-letter words containing 2I, 2O, S and 2U

CIRCUMLOCUTIONScircumlocutions n. Plural of circumlocution.
CIRCUMLOCUTION n. an overly complicated means of expression.
CIRCUMVOLUTIONScircumvolutions n. Plural of circumvolution.
CIRCUMVOLUTION n. anything winding or sinuous.
DISCONTINUOUSLYdiscontinuously adv. In a discontinuous manner; not continuously.
DISCONTINUOUS adv. not continuous.
IMMUNODIFFUSIONimmunodiffusion n. A technique used to detect the reaction between an antigen and an antibody by observing the behavior…
IMMUNODIFFUSION n. any of various analytical techniques that involve antigen and antibody solutions diffusing toward each other in a gel until antibody binds specifically to antigen to form a precipitate.
IMMUNOGLOBULINSimmunoglobulins n. Plural of immunoglobulin.
IMMUNOGLOBULIN n. an immune protein.
INCONSPICUOUSLYinconspicuously adv. In an inconspicuous manner; so as not to attract attention or appear unusual or out of the ordinary.
INCONSPICUOUS adv. not easily seen.
UNCONSCIENTIOUSunconscientious adj. Not conscientious.
UNCONSCIENTIOUS adj. not conscientious.
UNFOSSILIFEROUSunfossiliferous adj. Not fossiliferous, nonfossiliferous.
UNFOSSILIFEROUS adj. not fossiliferous.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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