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There are 8 twelve-letter words containing I, N, 4O and S

NONPOISONOUSnonpoisonous adj. Not poisonous.
non-poisonous adj. Alternative spelling of nonpoisonous.
NONPOISONOUS adj. not poisonous.
ODONTOLOGIESODONTOLOGY n. the study of teeth.
ODONTOLOGISTodontologist n. One who studies teeth.
ODONTOLOGIST n. a student of odontology.
ONOMASIOLOGYonomasiology n. (Linguistics) A branch of lexicology concerned with the names of concepts.
ONOMASIOLOGY n. the branch of semantics concerned with the meanings of and meaning relations between individual words.
OPISTHOTONOSopisthotonos n. (Medicine) Sustained tetanic spasm in which the body is bent backwards and stiffened, as produced by various diseases.
OPISTHOTONOS n. extreme arching backwards of the spine and neck as a result of spasm of the muscles in that region, etc.
PODOCONIOSESPODOCONIOSIS n. endemic elephantiasis of the lower legs.
PODOCONIOSISpodoconiosis n. (Pathology) An endemic form of nonfilarial elephantiasis.
PODOCONIOSIS n. endemic elephantiasis of the lower legs.
POGONOTOMIESPOGONOTOMY n. shaving.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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