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There are 16 twelve-letter words containing I, 2M, O, P, S and U

AMPHISTOMOUSamphistomous adj. (Zoology) Having a sucker at each extremity.
AMPHISTOMOUS adj. having a sucker at either end, as some worms.
AUTOMORPHISMautomorphism n. (Algebra) An isomorphism of a mathematical object or system of objects onto itself.
automorphism n. The ascription to others of one’s own characteristics.
AUTOMORPHISM n. ascription to others of one's own characteristics.
IMPOSTHUMATEimposthumate v. To apostemate; to form an imposthume or abscess.
IMPOSTHUMATE v. to form or inflict an abscess, also IMPOSTUMATE.
IMPOSTUMATEDIMPOSTUMATE v. to form or inflict an abscess, also IMPOSTHUMATE.
IMPOSTUMATESIMPOSTUMATE v. to form or inflict an abscess, also IMPOSTHUMATE.
IMPOUNDMENTSimpoundments n. Plural of impoundment.
IMPOUNDMENT n. the act of impounding.
LITHOSPERMUMlithospermum n. (Botany) Any plant of the genus Lithospermum.
Lithospermum prop.n. A taxonomic genus within the family Boraginaceae – the stoneseeds and gromwells.
LITHOSPERMUM n. a kind of flower.
LUMPECTOMIESlumpectomies n. Plural of lumpectomy.
LUMPECTOMY n. the surgical removal of a lump, esp. in the breast, aka tylectomy.
MISCOMPUTINGmiscomputing v. Present participle of miscompute.
MISCOMPUTE v. to compute erroneously.
PANDEMONIUMSpandemoniums n. Plural of pandemonium.
PANDEMONIUM n. riotous uproar, also PANDAEMONIUM.
POSTLIMINIUMpostliminium n. (Historical, Roman antiquity) The return to his own country, and his former privileges, of a person…
postliminium n. (Law) The right by virtue of which persons and things taken by an enemy in war are restored to their…
POSTLIMINIUM n. the right by which persons and property seized in war are restored to their former status on recovery, also POSTLIMINY.
PRASEODYMIUMpraseodymium n. A chemical element (symbol Pr) with an atomic number of 59, a soft, silvery, malleable and ductile metal…
PRASEODYMIUM n. a chemical element, a metal with green salts, isolated from the once-supposed element didymium.
PROGYMNASIUMprogymnasium n. In Germany, a classical school without the higher classes; a school preparatory to a gymnasium.
PROGYMNASIUM n. in Germany, a gymnasium for pupils up to age 16 only, at which university entrance qualifications are not obtainable.
RUMGUMPTIONSRUMGUMPTION n. (Scots) common sense, also RUMBLEGUMPTION, RUMELGUMPTION, RUMLEGUMPTION, RUMMELGUMPTION, RUMMLEGUMPTION.
SPERMAGONIUMspermagonium n. (Lichenology) Alternative spelling of spermogonium.
SPERMAGONIUM n. a receptacle in which spermatia are produced in some fungi and lichens.
SPERMOGONIUMspermogonium n. (Lichenology) A conceptacle of certain lichens, containing spermatia.
SPERMOGONIUM n. a flask-shaped structure in some fungi, also SPERMOGONE.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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