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There are 16 twelve-letter words containing 2I, 2S, T and 2U

DISPUTATIOUSdisputatious adj. Of or relating to something that is in question as to its intent or value.
disputatious adj. Inclined to argue or debate; provoking debate.
DISPUTATIOUS adj. inclined to dispute.
DISQUIETUDESdisquietudes n. Plural of disquietude.
DISQUIETUDE n. anxiety, agitation.
MULTICUSPIDSmulticuspids n. Plural of multicuspid.
MULTICUSPID n. a multicuspid tooth.
SOLITUDINOUSsolitudinous adj. Characterised by solitude.
SOLITUDINOUS adj. related to solitude.
SUBAUDITIONSsubauditions n. Plural of subaudition.
SUBAUDITION n. understanding of something not expressed.
SUBMUNITIONSsubmunitions n. Plural of submunition.
SUBMUNITION n. any of a group of smaller weapons carried as a warhead by a missile or projectile and expelled as the carrier approaches its target.
SUBSTITUTINGsubstituting v. Present participle of substitute.
SUBSTITUTE v. to put or use in the place of another.
SUBSTITUTIONsubstitution n. The act of substituting or the state of being substituted.
substitution n. A substitute or replacement.
substitution n. (Chemistry, especially organic chemistry) The replacement of an atom, or group of atoms, in a compound, with another.
SUBSTITUTIVEsubstitutive adj. Characteristic of, or serving as a substitute.
SUBSTITUTIVE adj. serving or suitable as a substitute.
SUPPOSITIOUSsuppositious adj. Spurious; substituted for the genuine, counterfeit; fake; supposititious.
suppositious adj. Imaginary; fictitious, pretended to exist.
suppositious adj. Hypothetical, based on supposition; suppositional.
TUMULOSITIEStumulosities n. Plural of tumulosity.
TUMULOSITY n. the state of being tumulose, full of small hills or mounds.
UNCTUOSITIESunctuosities n. Plural of unctuosity.
UNCTUOSITY n. the state of being unctuous.
UNFASTIDIOUSunfastidious adj. Not fastidious.
UNFASTIDIOUS adj. not fastidious.
UNSOLICITOUSunsolicitous adj. Not solicitous.
UNSOLICITOUS adj. not solicitous.
UNSUSTAININGunsustaining adj. That does not sustain.
UNSUSTAINING adj. not sustaining.
USTILAGINOUSustilaginous adj. Alternative form of ustilagineous.
USTILAGINOUS adj. relating to a genus of basidiomycetous fungi, of the family Ustilaginaceae, also USTILAGINEOUS.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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