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There are 3 twelve-letter words containing 2I, M, O, P, R and X

EXPROMISSIONexpromission n. (Law) The intervention of a new debtor, substituted for the former one, who is consequently discharged…
EXPROMISSION n. relieving another person's debt by taking it upon oneself.
PROXIMATIONSproximations n. Plural of proximation.
PROXIMATION n. immediate nearness in time, place, relationship, etc., also PROXIMITY.
PYRIDOXAMINEpyridoxamine n. (Biochemistry) A constituent of vitamin B6, essential for the metabolism of starch and amino acids.
PYRIDOXAMINE n. a crystalline amine of the vitamin B6 group.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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