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There are 14 twelve-letter words containing 2I, 2M and 3S

ASTIGMATISMSastigmatisms n. Plural of astigmatism.
ASTIGMATISM n. a defect in the eye or a lens by which rays from a single source are not focused at a single point, also ASTIGMIA.
CHEMIOSMOSISchemiosmosis n. (Chemistry) Any chemical reaction that occurs through an intervening semipermeable membrane, especially…
CHEMIOSMOSIS n. the mechanism by which the synthesis and utilization of the biochemical energy source ATP is regulated.
COMMISSAIREScommissaires n. Plural of commissaire.
COMMISSAIRE n. in professional cycle racing, a referee who travels in an open-topped car with the riders to witness any infringement of the rules.
COMMISSARIEScommissaries n. Plural of commissary.
COMMISSARY n. one to whom is committed some charge, duty, or office, by a superior power.
COSMETICISMSCOSMETICISM n. the use of cosmetics.
ISOMORPHISMSisomorphisms n. Plural of isomorphism.
ISOMORPHISM n. similarity in shape or structure in unrelated forms.
MANUMISSIONSmanumissions n. Plural of manumission.
MANUMISSION n. the act of manumitting; freeing from slavery.
MISEMPHASISEmisemphasise v. Alternative form of misemphasize.
MISEMPHASISE v. to emphasise wrongly, also MISEMPHASIZE.
MISERABLISMSMISERABLISM n. the quality of seeming to enjoy being depressed by gloomy art or music, also MISERABILISM.
MISESTIMATESmisestimates v. Third-person singular simple present indicative form of misestimate.
misestimates n. Plural of misestimate.
MISESTIMATE v. to estimate wrongly.
MONASTICISMSmonasticisms n. Plural of monasticism.
MONASTICISM n. the monastic system or mode of life, also MONACHISM.
NUMISMATISTSnumismatists n. Plural of numismatist.
NUMISMATIST n. a coin collector.
SHUNAMITISMSSHUNAMITISM n. rejuvenation of an old man by a young woman.
SWIMMINGNESSswimmingness n. The act or state of swimming; suffusion.
SWIMMINGNESS n. the state of being swimming.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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