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There are 3 eight-letter words containing 2I, P, 2R and U

PRURITICpruritic adj. (Medicine) Intensely itchy.
PRURITIC adj. of or like pruritus, itching of the skin.
PURIFIERpurifier n. A person or device that purifies (by removing impurities).
PURIFIER n. one that purifies.
SIRUPIERSIRUPY adj. like sirup.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the 1Word.ws and WikWik.org.

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