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There are 10 eight-letter words containing 2I, O and 3S

CISSOIDScissoids n. Plural of cissoid.
CISSOID n. a type of geometric curve.
FISSIONSfissions n. Plural of fission.
FISSION v. to split into parts.
ISOSPINSisospins n. Plural of isospin.
ISOSPIN n. a quantum number applied to members of closely related groups of particles.
MIOSISESMIOSIS n. (Greek) excessive contraction of the pupil of the eye, also MYOSIS.
MISSIONSmissions n. Plural of mission.
missions v. Third-person singular simple present indicative form of mission.
MISSION v. to send to perform a specific task.
OSSIFIESossifies v. Third-person singular simple present indicative form of ossify.
OSSIFY v. to change into bone; to become callous or conventional.
PISSOIRSpissoirs n. Plural of pissoir.
PISSOIR n. (French) a public urinal.
PSILOSISpsilosis n. (Phonology) The sound change by which Greek lost the consonant sound /h/ during antiquity.
psilosis n. (Medicine) Sprue, a disease of the small intestine.
PSILOSIS n. (Greek) loss of hair.
SCISSIONscission n. The act of division, separation, cutting, cleaving, or severing; cleavage.
SCISSION n. a division or split in a group or union.
SEMIOSISsemiosis n. (Semiotics) Any activity, conduct, or process that involves signs, including the production of meaning.
SEMIOSIS n. (Greek) a process in which something functions at organism.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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