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There are 2 eight-letter words containing 2I, O, P, T and Z

EPIZOITEepizoite n. Any epizoic organism.
EPIZOITE n. an epizoic organism.
OPTIMIZEoptimize v. (Originally intransitive) To act optimistically or as an optimist.
optimize v. (Transitive) To make (something) optimal.
optimize v. (Transitive) To make (something) more efficient, such as a computer program.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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