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There are 2 eight-letter words containing 3I, L, R and S

VIRILISEvirilise v. Alternative form of virilize.
VIRILISE v. to introduce male characteristics in (a female), also VIRILIZE.
VIRILISMvirilism n. The condition resulting from virilization in a female.
VIRILISM n. the development of male sex characteristics in a female.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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