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There are 3 twelve-letter words containing 2I and 4O

OPISTHODOMOIopisthodomoi n. Plural of opisthodomos.
OPISTHODOMOS n. (Greek) a portico or apartment at the back of an ancient Greek or Roman temple.
PODOCONIOSISpodoconiosis n. (Pathology) An endemic form of nonfilarial elephantiasis.
PODOCONIOSIS n. endemic elephantiasis of the lower legs.
SOCIOBIOLOGYsociobiology n. The science that applies the principles of evolutionary biology to the study of social behaviour in…
SOCIOBIOLOGY n. the study of the biological basis of human behaviour.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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