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There are 5 twelve-letter words containing 2I, M, 2O and X

EXPROMISSIONexpromission n. (Law) The intervention of a new debtor, substituted for the former one, who is consequently discharged…
EXPROMISSION n. relieving another person's debt by taking it upon oneself.
IMMUNOTOXINSimmunotoxins n. Plural of immunotoxin.
IMMUNOTOXIN n. a toxin with immunosuppressive effects.
MOXIBUSTIONSmoxibustions n. Plural of moxibustion.
MOXIBUSTION n. cauterization by use of moxa.
PROXIMATIONSproximations n. Plural of proximation.
PROXIMATION n. immediate nearness in time, place, relationship, etc., also PROXIMITY.
TOXICOMANIAStoxicomanias n. Plural of toxicomania.
TOXICOMANIA n. a morbid craving for poisons.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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