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There are 13 ten-letter words containing 2I, R, S and 2U

CIRCUITOUScircuitous adj. Not direct or to the point.
circuitous adj. Of a long and winding route.
CIRCUITOUS adj. having a circular or winding course.
FUTURISTICfuturistic adj. Of technology, a concept, etc, so far advanced as to appear to be from the future.
FUTURISTIC adj. of or relating to futurism, an artistic movement.
FUTURITIESfuturities n. Plural of futurity.
FUTURITY n. the state of being in the future.
HIRUDINOUSHIRUDINOUS adj. of or like hirudin, a substance present in the salivary glands of leeches, used as an anticoagulant.
LUBRICIOUSlubricious adj. Smooth and glassy; slippery.
lubricious adj. Lewd, wanton, salacious or lecherous.
LUBRICIOUS adj. slippery; lewd, also LUBRIC, LUBRICAL, LUBRICOUS.
NUTRITIOUSnutritious adj. (Of food or drink) Providing nutrients; healthy to eat.
nutritious adj. (Figurative) Salutary.
NUTRITIOUS adj. giving nourishment.
RIDICULOUSridiculous adj. Deserving of ridicule; foolish, absurd.
ridiculous adj. (Informal) astonishing, extreme, unbelievable.
RIDICULOUS adj. arousing or deserving ridicule.
RUBIGINOUSrubiginous adj. Alternative form of rubiginose.
RUBIGINOUS adj. rust-coloured, also RUBIGINOSE.
SPIRITUOUSspirituous adj. Of, pertaining to, containing, or made using alcohol.
spirituous adj. (Of an alcoholic drink) Distilled.
SPIRITUOUS adj. alcoholic.
SUBCIRCUITsubcircuit n. A distinct part of an electrical or other circuit.
subcircuit n. (Mathematics) A subset of a circuit.
SUBCIRCUIT n. a part of a circuit.
SUSPIRIOUSsuspirious adj. Suspiring; sighing.
SUSPIRIOUS adj. breathing labouredly; sighing.
UREDINIUMSUREDINIUM n. a uredosorus, a sorus or pustule in which urediniospores are formed, also UREDIUM.
URICOSURICuricosuric adj. (Medicine) Pertaining to gout suppressants that act directly on the renal tubule to increase the excretion…
uricosuric n. Any medicine of this kind.
URICOSURIC adj. promoting the excretion of uric acid.

Scrabble words — in black are valid world wide — in RED are not valid in North America — in GREEN are valid only in North America.
Definitions are short excerpt from the WikWik.org and 1Word.ws.

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